· 哈佛大学丹娜法伯癌症研究院免疫效应细胞治疗项目医学主管

· 哈佛医学院讲师

【专长领域】

· 慢性髓系白血病

· 霍奇金淋巴瘤

· 非霍奇金淋巴瘤

【研究方向】

· CAR-T

· 淋巴瘤

【教育背景】

2004年毕业于哥伦比亚大学医学院，获得博士学位

2008年于纽约长老会医学院完成实习和内科学住院医培训

2011年于丹娜法伯癌症研究所完成血液/肿瘤学专科培训

【学术著作】(摘选)

1. Autologous Stem Cell Transplantation in Elderly Lymphoma Patients in Their 70s: Outcomes and Analysis. Sun L, Li S, El-Jawahri A, Armand P, Dey BR, Fisher DC, Jacobsen ED, Jacobson CA, LaCasce AS, McAfee SL, Spitzer TR, Chen YB, DeFilipp Z. Oncologist. 2017 Dec 28. pii: theoncologist.2017-0499. doi: 10.1634/theoncologist.2017-0499.

70几岁的淋巴瘤老年患者接受自体干细胞移植治疗的疗效和分析

2. Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma. Neelapu SS, Locke FL, Bartlett NL, Lekakis LJ, Miklos DB, Jacobson CA, Braunschweig I, Oluwole OO, Siddiqi T, Lin Y, Timmerman JM, Stiff PJ, Friedberg JW, Flinn IW, Goy A, Hill BT, Smith MR, Deol A, Farooq U, McSweeney P, Munoz J, Avivi I, Castro JE, Westin JR, Chavez JC, Ghobadi A, Komanduri KV, Levy R, Jacobsen ED, Witzig TE, Reagan P, Bot A, Rossi J, Navale L, Jiang Y, Aycock J, Elias M, Chang D, Wiezorek J, Go WY. N Engl J Med. 2017 Dec 28;377(26):2531-2544. doi: 10.1056/NEJMoa1707447. Epub 2017 Dec 10.

Axicabtagene Ciloleucel CAR-T细胞治疗难治性大B细胞淋巴瘤

3. Relapsed or Refractory Double-Expressor and Double-Hit Lymphomas Have Inferior Progression-Free Survival After Autologous Stem-Cell Transplantation. Herrera AF, Mei M, Low L, Kim HT, Griffin GK, Song JY, Merryman RW, Bedell V, Pak C, Sun H, Paris T, Stiller T, Brown JR, Budde LE, Chan WC, Chen R, Davids MS, Freedman AS, Fisher DC, Jacobsen ED, Jacobson CA, LaCasce AS, Murata-Collins J, Nademanee AP, Palmer JM, Pihan GA, Pillai R, Popplewell L, Siddiqi T, Sohani AR, Zain J, Rosen ST, Kwak LW, Weinstock DM, Forman SJ, Weisenburger DD, Kim Y, Rodig SJ, Krishnan A, Armand P. J Clin Oncol. 2017 Jan;35(1):24-31. Epub 2016 Oct 24.

复发或难治性双表达和双重打击淋巴瘤自体干细胞移植后无进展生存期较差

4. Idelalisib given front-line for treatment of chronic lymphocytic leukemia causes frequent immune-mediated hepatotoxicity. Lampson BL, Kasar SN, Matos TR, Morgan EA, Rassenti L, Davids MS, Fisher DC, Freedman AS, Jacobson CA, Armand P, Abramson JS, Arnason JE, Kipps TJ, Fein J, Fernandes S, Hanna J, Ritz J, Kim HT, Brown JR. Blood. 2016 Jul 14;128(2):195-203. doi: 10.1182/blood-2016-03-707133. Epub 2016 May 31.

将艾德拉尼作为慢性淋巴细胞白血病的一线用药会引起频繁的免疫介导的肝毒性

5. Detection of activating MAP2K1 mutations in atypical hairy cell leukemia and hairy cell leukemia variant. Mason EF, Brown RD, Szeto DP, Gibson CJ, Jia Y, Garcia EP, Jacobson CA, Dal Cin P, Kuo FC, Pinkus GS, Lindeman NI, Sholl LM, Aster JC, Morgan EA. Leuk Lymphoma. 2017 Jan;58(1):233-236. Epub 2016 May 31.

在非典型性毛细胞白血病和毛细胞白血病变体中检测激活的MAP2K1突变