· 哈佛医学院丹娜法伯癌症研究院高级医师

· 哈佛医学院助理教授

【专长领域】

· 肛门癌

· 胆管癌

· 结肠癌

· 食管癌

· 胆囊癌

· 胃肠道良性肿瘤

· 肝癌

· 神经内分泌良性肿瘤

· 胰腺癌

· 直肠癌

· 胃癌

【教育背景】

2000年毕业于托马斯杰斐逊大学医学院，获得博士学位

2003年于密歇根大学医学院完成内科学住院医培训

2006年于密歇根大学医学院完成血液/肿瘤学专科培训

【从医荣誉】(摘选)

1999年荣获Hobart Amory Hare Honor Medical Society

2001年荣获密歇根大学优秀实习生

2006年荣获NIH Ruth L. Kirschstein 国家研究服务奖

【学术著作】(摘选)

1. A multicenter phase II trial of single-agent cetuximab in advanced esophageal and gastricadenocarcinoma. Chan JA1, Blaszkowsky LS, Enzinger PC, Ryan DP, Abrams TA, Zhu AX, Temel JS, Schrag D, Bhargava P, Meyerhardt JA, Wolpin BM, Fidias P, Zheng H, Florio S, Regan E, Fuchs CS. Ann Oncol. 2011 Jun;22(6):1367-73. doi: 10.1093/annonc/mdq604. Epub 2011 Jan 7.

单药西妥昔单抗治疗晚期食管癌和胃腺癌的多中心II期临床试验

2. Patterns of Chemotherapy Use in a U.S.-Based Cohort of Patients with Metastatic Pancreatic Cancer. Abrams TA, Meyer G, Meyerhardt JA, Wolpin BM, Schrag D, Fuchs CS. Oncologist. 2017 Aug;22(8):925-933. doi: 10.1634/theoncologist.2016-0447. Epub 2017 May 5.

美国转移性胰腺癌患者使用的化疗模式

3. A phase 2 and biomarker study of cabozantinib in patients with advanced cholangiocarcinoma. Goyal L, Zheng H, Yurgelun MB, Abrams TA, Allen JN, Cleary JM, Knowles M, Regan E, Reardon A, Khachatryan A, Jain RK, Nardi V, Borger DR, Duda DG, Zhu AX. Cancer. 2017 Jun 1;123(11):1979-1988. doi: 10.1002/cncr.30571. Epub 2017 Feb 13.

卡博替尼苹果酸盐在晚期胆管癌患者中生物标志物的Ⅱ期研究

4. A phase I and pharmacokinetic study of ganetespib (STA-9090) in advanced hepatocellular carcinoma. Goyal L, Wadlow RC, Blaszkowsky LS, Wolpin BM, Abrams TA, McCleary NJ, Sheehan S, Sundaram E, Karol MD, Chen J, Zhu AX. Invest New Drugs. 2015 Feb;33(1):128-37. doi: 10.1007/s10637-014-0164-8. Epub 2014 Sep 24.

Ganetespib在晚期肝细胞癌患者中的药代动力学Ⅰ期研究

5. Delaying chemoradiation until after completion of adjuvant chemotherapy for pancreatic cancer may not impact local control. Wo JY, Childs SK, Szymonifka J, Mamon HJ, Ryan DP, Blaszkowsky LS, Kwak EL, Ferrone CR, Allen JN, Zhu AX, Wolpin BM, Chan JA, Abrams TA, McCleary NJ, Fernandez-del Castillo C, Hong TS. Pract Radiat Oncol. 2014 Mar-Apr;4(2):e117-23. doi: 10.1016/j.prro.2013.07.006. Epub 2013 Aug 9.

胰腺癌患者完成辅助化疗后才结束放化疗可能不会影响病灶的局部控制

6. Multi-drug inhibition of the HER pathway in metastatic colorectal cancer: results of a phase I study of pertuzumab plus cetuximab in cetuximab-refractory patients. Rubinson DA, Hochster HS, Ryan DP, Wolpin BM, McCleary NJ, Abrams TA, Chan JA, Iqbal S, Lenz HJ, Lim D, Rose J, Bekaii-Saab T, Chen HX, Fuchs CS, Ng K. Invest New Drugs. 2014 Feb;32(1):113-22. doi: 10.1007/s10637-013-9956-5. Epub 2013 Apr 9.

转移性结直肠癌中HER途径的多药物抑制：对西妥昔单抗难治性患者使用帕妥珠单抗联合西妥昔单抗的I期研究结果