Que博士是杜克大学内科学的终身助理教授，在杜克大学医学中心就职，是美国肺脏协会的主要研究人员，也是杜克大学肺病临床研究组的主任，也是哮喘、过敏和气道中心的研究主任。曾担任美国胸腔协会主席。

Que博士目前主要研究一氧化氮和相关酶在肺病发病机制中的作用，特别是由亚硝化/氧化应激引起的肺部疾病，研究 在细胞培养中进行并应用于动物模型，然后在相关的人类疾病中进行。Que博希望通过更好地了解NO和活性氮在介导炎症和调节细胞信号传导中的作用，揭示NO相关肺病的基本机制，同时为使用NO靶向治疗提供理论依据。

【专长领域】

哮喘

气道高反应

COPD

其他肺病疾病

【教育背景】

1989年于芝加哥大学取得医学博士学位

1989-1992于耶鲁大学进行住院医师培训

1992-1993年于耶鲁大学担任临床导师

1993-1996年于杜克大学进行肺病专科培训

【研究资助】(摘选)

· A Longitudinal Prospective Observational Study of the Characteristics, Treatment Patterns and Health Outcomes of Individuals with Severe Asthma in the United States

· CXCL10/CXCR3 regulation of ozone-induced epithelial permeability

· Research Training in Allergy and Clinical Immunology

· Mechanisms that Direct Airway Remodeling in Obese Asthma

· Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRI

· Interdisciplinary Training Program in Lung Disease

· Trial of Roflumilast in Asthma Management (TRIM)

【学术著作】(摘选)

Que, LG, Yang, Z, Lugogo, NL, Katial, RK, Shoemaker, SA, Troha, JM, Rodman, DM, Tighe, RM, and Kraft, M. "Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma." Immunity, Inflammation and Disease 6, no. 2 (June 2018): 322-331.

硝基谷胱甘肽还原酶抑制剂N6022对哮喘支气管高反应性的影响

Durack, J, Lynch, SV, Nariya, S, Bhakta, NR, Beigelman, A, Castro, M, Dyer, A-M, Israel, E, Kraft, M, Martin, RJ, Mauger, DT, Rosenberg, SR, Sharp-King, T, White, SR, Woodruff, PG, Avila, PC, Denlinger, LC, Holguin, F, Lazarus, SC, Lugogo, N, Moore, WC, Peters, SP, Que, L, Smith, LJ, Sorkness, CA, Wechsler, ME, Wenzel, SE, Boushey, HA, Huang, YJ, National Heart, and Lung and Blood Institute's “AsthmaNet”, . "Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment." The Journal of Allergy and Clinical Immunology 140, no. 1 (July 2017): 63-75.

与过敏、哮喘有关的支气管细菌微生物群的特点及对吸入皮质类固醇治疗的反应

He, M, Driehuys, B, Que, LG, and Huang, Y-CT. "Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution." Academic Radiology 23, no. 12 (December 2016): 1521-1531.

使用超极化 129xeMRI检查对肺通气分布定量

Ray, S, Chiba, N, Yao, C, Guan, X, McConnell, AM, Brockway, B, Que, L, McQualter, JL, and Stripp, BR. " Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection." Stem Cell Reports 7, no. 5 (November 2016): 817-825.

罕见的 sox2 + 气道祖细胞产生 krt5 + 细胞,重新修复流感病毒感染后受损的肺泡实质。